All About Lithium Orotate You Should Know
What is Lithium orotate?
Lithium orotate, is a salt of orotic acid and lithium. It is available as the monohydrate, LiC5H3N2O4·H2O. In this compound, lithium is non-covalently bound to an orotate ion, rather than to a carbonate or other ion. It is marketed as a dietary supplement, though only barely researched between 1973-1986 to treat certain medical conditions, such as alcoholism, and Alzheimer's disease.
Lithium orotate is capable of providing lithium to the body, like lithium carbonate and other lithium salts. In the human body, orotic acid can be produced from microorganisms found in the intestines.
History
Lithium (not specifically the orotate salt) has been associated with curative properties in Greek literature for centuries, while visits to natural lithium-enriched waters were reportedly undertaken by Mark Twain, Grover Cleveland, and Theodore Roosevelt, among others, in the 19th century. A lithium citrate–containing beverage was marketed as "lithiated lemon soda" in the mid 1900s, apparently to make it seem healthier. Lithium has been associated with longevity in Japanese literature, and historically was considered beneficial in treating hepatitis.
Chemistry
Lithium orotate is the commercially available monohydrate salt of the metal lithium and orotic acid. Based on the degree of ionization of the different salt forms, with an orotate salt in general being less ionisable and more bioavailable than a gluconate salt, earlier studies suggest that the orotate form is able to cross the blood-brain barrier more easily than the carbonate form.
Studies claiming differences in the pharmacokinetics of lithium orotate salt versus the carbonate and chloride forms have been disputed. No differences were found in the uptake, distribution, and clearance of the lithium ion in rat studies, despite early research suggesting lithium orotate achieved higher concentrations in the brain.
Basic Information
Product Name: Lithium Orotate
Purity: 99%min
Appearance: White crystalline powder
CAS No.: 5266-20-6
EINECS: 226-081-4
Molecular formula: C5H4N2O4.Li
Molecular weight: 180.0446
How Does Lithium Orotate Work?
For your body to utilize lithium, a transporter molecule must transport it. In case of lithium orotate, the transporter is vitamin B-13 (orotic acid), a compound that your body produces naturally.
Lithium orotate provides（5266-20-6） superior bio-utilization. This allows the mineral to penetrate through the cell’s intracellular structures, including the glia, lysosomes, and mitochondria.
Lithium helps in management of mental disorders by boosting chemical messenger’s activity in the brain.
Recent studies have shown that mood stabilization effects of lithium may be as a result of its ability to increase the rate of neurogenesis (production of new brain cells).
Lithium inhibits GSK-3β (enzyme glycogen synthase kinase-3β). The inhibition upregulates IGF-1 (insulin-like growth factor-1) and BDNF (brain-derived neurotrophic factor), which commands neural stem cells to start producing new neurons.
Whenever neural stem cells produces new neurons, memory and mood function as designed. However, neurogenesis breakdown causes mood disorders. Lithium also works to protect your brain.
The lithium salt of orotic acid (lithium orotate) improves the specific effects of lithium many-fold by increasing lithium bio-utilization. The orotates transport the lithium to the membranes of mitochondria, lysosomes and the glia cells. Lithium orotate stabilizes the lysosomal membranes and prevents the enzyme reactions that are responsible for the sodium depletion and dehydration effects of other lithium salts.
Because of the superior bioavailability of lithium orotate, the therapeutic dosage is much less than prescription forms of lithium. For example, in cases of severe depression, the therapeutic dosage of lithium orotate is 150 mg/day. This is compared to 900-1800 mg of the prescription forms. In this dosage range of lithium orotate, there are no adverse lithium side reactions and no need for monitoring blood serum measurements.
Lithium Orotate Applications
Lithium orotate is a dietary supplement that can be used in small doses to treat conditions like manic depression, alcoholism, ADHD and ADD, depression, aggression, PTSD, Alzheimer's Disease and overall stress management.
Lithium orotate has also been used with success in alleviating the pain from migraine and cluster headaches, low white blood cell counts, juvenile convulsive disease, alcoholism and liver disorders. And it is also reported that patients with myopia (nearsightedness) and glaucoma often benefit from the slight dehydrating effect of lithium on the eye, resulting in improvement in vision and reduction of intraocular pressure.
Current Research in Lithium Orotate
Prescription-strength lithium orotate is regarded as a potent neuroprotective agent. It is being widely studied in specific neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease, and ALS (amyotrophic lateral sclerosis). It has been proved to cause disruption of glycogen synthase kinase-3, which is a crucial enzyme that causes the development of neurofibrillary tangles and amyloid plaques that are associated with A.D. (Alzheimer’s disease.)
Safty of Lithium Orotate
Lithium orotate's safety remains in question. Concerns have been raised in medical literature after a case report of a patient who required medical attention after taking an overdose of lithium orotate supplement.
Orotic acid can be mutagenic in very high doses of 50 mg/kg in mammalian somatic cells. It is also mutagenic for bacteria and yeast
Where you can order Lithium Orotate?
With people becoming more and more aware of the benefits of Lithium Orotate , the demand for Lithium Orotate supplements has increased greatly in the market. This has led to manufacturing companies vying with each other to produce high-quality supplements to grab share in the market. If you are a health supplements manufacturer planning to foray into the Lithium Orotate supplements market, you must ensure that you are getting the highest-quality Lithium Orotate powder. Sourcing good-quality material is the first step in ensuring the success of any business.
If you are looking for a place to buy Lithium Orotate powder in bulk, the one company you can blindly trust for sourcing raw material is Cofttek. The company, owing to its strong research team and dedicated sales department, has established a worldwide presence in only a short amount of time — it has clients and partners around the world. The Lithium Orotate produced by the company comes in big batches of 25 kgs and is sourced from highest-quality ingredients, thereby ensuring that the supplements produced from it can be trusted for quality and efficacy. If you want to buy Lithium Orotate in bulk, the only place to shop is cofttek.com.
[1]. Ina Bach; Otto Kumberger; Hubert Schmidbaur (1990). "Orotate complexes. Synthesis and crystal structure of lithium orotate( - I) monohydrate and magnesium bis[ orotate( - I)] octahydrate". Chemische Berichte. 123 (12): 2267–2271. doi: 10.1002/cber.19901231207.
[2]. Sartori HE (1986). "Lithium orotate in the treatment of alcoholism and related conditions". Alcohol. 3 (2): 97–100. doi: 10.1016/0741-8329 (86)90018-2. PMID 3718672
[3]. Nieper, Hans Alfred (1973), "The clinical applications of lithium orotate. A two years study", Agressologie, 14(6): 407–11, PMID 4607169
[4]. Smith DF (April 1976). "Lithium orotate, carbonate, and chloride: pharmacokinetics, polydipsia and polyuria in rats". British Journal of Pharmacology. 56 (4): 399–402. doi:10.1111/j.1476-5381. 1976.tb07449.x. PMC 1666891. PMID 1260219.
[5]. Kidney function and lithium concentrations of rats given an injection of lithium orotate or lithium carbonate. Smith DF, Schou M. J Pharm Pharmacol. 1979 Mar;31(3):161-3. doi: 10.1111/j.2042-7158.1979.tb13461.x.PMID: 34690